Care to elaborate? The last B757 had production complete October 28th, 2004. This puts the youngest model at a decade old. The oldest possible B757 would be around 34 years old. Not exactly what would be considered 'new'.
Further, given that the design originated from work in the 70's, many of the current aircraft innovations which can increase efficiency and/or reduce operating cost are either not present, or not quite as effective if retrofitted.
Winglets (like on the C-17 for instance) can increase fuel efficiency, yet a stock B757 does not have them.
Same goes for a number of other developments. Also given the length of time the design has been out of production, some of the maintenance and support activities are going to be more expensive. That is one of many reasons why a B-52 would have such a high operating cost. The last B-52 (an -H model) was produced in 1962, and despite how many SLEP and kit modernizations and upgrades, any combat aircraft that is still on active duty after 50+ years is going to be expensive to operate. The amount of resources required to ensure that the airframe alone is not suffering from a dangerous degree of metal fatigue would be significant. Nevermind that the engines and fuel burn rate would not be as high as possible with a more modern design due to materials, placement, and overall aircraft design. After all, the design originated from some discussions in 1948, about a possible new design to replace the B-47, which while it entered service in 1951 had initial design work start mid-war during WWII.
If people are really expecting a 1950's era heavy/strategic bomber (which is enormous BTW) to be efficient/inexpensive to operate...