I'm glad someone appreciated my math ;-)
To resolve some of the uncertainties over reactor usage, I dived into command histories of US SSNs (available on history.navy.mil and elsewhere).
1) Typical USN SSN deployments are 35,000 - 40,000 nm over ~6 months, with 70-80% of time underway and average speeds of advance of 11.5 to 12 knots
2) Over longer durations, including training and patrols in home waters, speeds of advance are somewhat lower (as would be expected ), approx. 10 knots
3) Over a 10 year operational cycle, average miles steamed is ~35,000 nm/year between major overhauls (SSN 690 Philadelphia - Los Angeles class)
4) Over the long run, including time spent in major overhauls, US SSNs average ~25,000 nm/year (500,000nm over 20 years for SSN 750 Newport News, 650,000nm over 25 years for SSN 684 Cavalla).
My takeaway: these numbers are in the same ballpark as the numbers I previously quoted for French Rubis class SSNs (40,000 nm/year during operational cycles, 33,000nm/year over 35+ years, 10 knot average speed of advance). If anything the Rubis class were used slightly more intensely in terms of distance travelled and time at sea (not really surprising with double crews), so even if their transit distances and speeds are lower, it all balances out. Their 240,000nm reactor life between refueling was sufficient for 6+ year operational cycles (French Optempo), which would be more like 7 years with the USN Optempo above. Take that and multiply by 1.25x to 1.5x for the Suffrens with their expected 10 years before refueling (or between refuelings? Not the same).
So anyway, bottom line is I'm not seeing any evidence of hugely different Optempos or deficiencies in LEU reactor life that would cause operational limitations.
One could of couse do sensitivity analyses around each of the variables above but it won't fundamentally change the results IMHO... because whether the cycle ends up being 7 years of high intensity operational use (e.g. with double crews) or 9-10 years of lower intensity operational use, the basic message is that even an LEU core with a 300,000+ nm life gets you significant mileage - enough to pack in multiple deployments and several hundred sea training days and enough to maintain a USN Optempo (or better). With ~3 refuelings needed for a 30+ year life, which are low impact and could all happen during regular docking periods.
(Again apologies for flogging a dead horse - but I hope some find these SSN op cycle details interesting)